I've noticed the same thing in 2 long haul flights I've done, around the 235klbs range. The rotation on the way out each time was more than an easy stick pull, it required an abnormal amount of backpressure to unstick.
I can provide a video of that if necessary, but I would say it is worth a test. This was at JFK, 236klbs, I believe CG came out to about 23% and 1.7 ANU. CG didn't seem right, but I generally fly the A320, so I have no idea; the loads were put in via the EFB.