While nearing desintation airport, I selected a runway and approach in the FMS but when I tried to click on "Insert TMPY" button, not only did the FMS freeze but all aircraft functions were unresponsive including all panel visual updates, couldn't lower landing gear, couldn't extend flaps, etc. I could still move the cursor around the cockpit and the sim continued to run fine. It was just the aircraft that no longer functioned.
A350-900 on MSFS2020 1.38.2.0