Well, it's the same for me.
After about 2 hours of flying, all the buttons froze, impossible to regain control. I tried 3 times to fly from EDDF to KDTW and the same thing happened each time.
It's annoying when, like me, you're building a career on PilotLife and have to start over.
With all these bugs on the A350 and A340, I lost 3% of my XP level.