I just had this issue for the first time in MSFS2020, just as I arrived at the gate after a 9h flight. This is my first flight on the new update after following the steps of deleting the WASM folder mentioned in the update notes. Screens are frozen apart from the EFB, buttons can be interacted with but do not have any effect. I was about to go through with shutting down the plane but turning off the master switches do nothing.